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Half of our 219 guestrooms are two-room suites. We feature 71 standard deluxe, 44 king deluxe, 52 Crowne Suites (king beds) and 52 Living Suites (double/doubles).

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West Palm Beach is an ideal destination to enjoy fine arts, with numerous art galleries, music groups, dance companies and theaters.

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The elegant Grand Ballroom, with 5000 square feet (465 square meters) of meeting space, can accommodate up to 650 guests in a reception style setting.

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The Crowne Plaza West Palm Beach is known for excellent dining.

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The Atrium Restaurant is located in our beautiful atrium and is open for breakfast, lunch and dinner. Hours of operation are 6:30am to 10:00pm. We offer a bountiful breakfast buffet daily and our lunch buffet is available Monday through Friday.

Our lobby bar, Atrium Lounge, offers your favorite beverage, appetizers and a full dinner menu in a comfortable, relaxed setting. Hours or operation are 5:00pm to 11:00pm.

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PETER CLARK

City Break Expert

Hockey fan, foodie, audiophile, vintage furniture lover and passionate about urban photography. Working to provide the best city break offers so you don’t have to stress about it. “You should enjoy the city, not worry about the trip’s details.”

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REBECCA GILBERT

Nature Trips Expert

Nature enthusiast, animal lover and passionate mountaineer. Your journey must be safe, efficient and convenient. “My mission is to create an unforgettable holiday because time has an essential role in everyone’s life.”

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DAVID HAWKINS

Exotic Destinations Expert

Skydiver, rock climber, surfer, kiter and lover of exotic fruits. “A “special” category of clients that I like is the newly married young people, whom I like to offer the journey of their lives in their honeymoon. A little something to help them get started.”

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Why You Should Consider Getting a Swiss Army Knife with a Saw

Swiss Army Knife

My husband is a gadget person, and I always know that type of item will please him when his birthday rolls around. And I wasn’t wrong when I chose to buy him a Victorinox Swiss Army Knife, in the Huntsman model, last year. This knife is so much more than just a knife, it is a toolbox! He has used this so many times, and just last week he used the saw portion to cut some bushes we were transplanting. The roots had gotten really tangled and overgrown, but this cut right through them in no time, and they were almost an inch thick!

Accessories On this Knife

Accessories On this Knife

Bottle cap remover
Can opener
Corkscrew
Key Ring
Large knife blade (2 3/8″ long)
Small knife blade
Large screwdriver (6mm)
Small screwdriver (3mm, will work with Phillips head)
Multi-purpose hook
Reamer /punch
Scissors
Sewing eye
Straight pin
Toothpick
Tweezers
Wire stripper
Wood saw (3″ long)

Does It Work Well?

Does It Work Well

Indeed it does! Some of the tools, like the can opener, are a bit primitive, but they get the job done, and that’s what this is for. The knife blades are extremely sharp, so I would recommend only adults use this knife. They lock in place too, which is nice. That helps when doing any serious cutting like trying to fillet a fish, cut through rope, or any other such job where the knife would be needed. You don’t want it slipping on you, and with the lock down feature it certainly won’t.

Only two of the accessories, the toothpick and pin, are removeable. The scissors get used a fair amount, and work great and haven’t dulled in a year. They have a nice spring action and work relatively easy despite their small size. We’ve used the corkscrew when we were out camping and someone in our party brought a bottle of wine and assumed we had a corkscrew in our motorhome – well we did, on this Swiss Army Knife! It has bailed us out more than once in the past year, read more from here.

The total length of this Victorinox Swiss Army Knife is 91 mm. It’s about 3 1/2″ long when closed and 3/4″ wide, so this is the perfect size to carry with you when you are out hiking, fishing or hunting. It only weighs 3.4 ounces (according to my postage scale). We live in Alaska, and my husband gets many opportunities to use this knife. He works on computers at work, and it has come in handy many times when he is in the middle of a job. I can’t tell you how valuable this set of tools has been to him.

I have tried to open the blades before, but I always struggle with them, although when I hand it to my husband to open, he gets it done in seconds. I guess this tool scares me a little, because I truly am afraid of cutting myself on those sharp knife blades. After using this for one year, I can attest to the fact that these knife blades are still sharp and hold their edges well! The steel blades work well for sharpening sticks for roasting marshmallows or hotdogs.

The bottle opener rarely gets used, since most bottle caps these days twist off. It seems like the company could have included another tool in it’s place, or omitted it all together. I’ve heard others say that a small magnifying glass would be a great help in starting fires – especially if you are stranded in the woods for any length of time. I don’t know if it’s possible to add a magnifying glass to a Swiss Army Knife, but it’s a thought.

regular pocket knife

This is a little bigger and fatter than a regular pocket knife, but is a nice size for a muli-function tool/knife combo. If you are an outdoorsman, this would be a perfect tool for you. If you are a wife looking for a gift for your husband, it would be hard to go wrong with this set of mini tools. I have seen this for sale all over the internet, and the price ranges are quite versatile, from $25 to $65, so shop around if you are looking to make a purchase.

Dry Erase Board Meme Revealed to Be Hoax: Jenny is Elyse Porterfield

Dry Erase Board Meme Revealed to Be Hoax

As pointed out in TechCrunch and later referred to in my Steven Slater article, Jenny the “HOPA/HPOA” dry erase board girl is yet another in a series of hoaxes by the makers of the $10,000 Trump Tip (see FoxNews) and Teen Texting Disaster (see Inquisitr) hoaxes, John and Leo Resig. “Jenny” reportedly sent a series of dry erase board images to her small brokerage office as a means of quitting her job. In the messages, she made it very clear she was quitting due to her sexist, foul-smelling boss, whom she exposed as a chronic office time waster.

It would have been a creative way to walk off a job, if any of it had been true. According to Long Island Press, Jenny is actually actress Elyse Porterfield, and the hoax, reportedly done for entertainment purposes, helped drive traffic to the Chive via Facebook shares (238,000) and Tweets (31,000, according to TechCrunch),To discover more information on internet meme, you’ve to check out our website.

From the famous “Piltdown Man” archaeological hoax of 1912 on, people want to believe the more extraordinary things we hear from friends, families, or things we’ve read to be real, in particular if we’ve read it from something we consider to be a reliable source. If you have access to the Internet, you’ve probably been hoaxed at some point or another.

Snopes.com has become an increasingly useful resource for those of us who wonder if that e-mail Mom or our co-worker forwarded is a real hunt for a tragically missing girl or if that guy in the picture e-mailed to us actually did the incredibly stupid thing they did (hint: probably not). Discovery Channel’s Mythbusters has also done a solid service in proving whether various urban legends, including those Internet and videos sourced, are plausible or wholly false.

Sometimes, as in the case of Jenny, if it sounds too good to be true, it isn’t true. LonelyGirl15 was an early YouTube phenomenon later proven to be a fraud. The apparently normal 16-year old named “Bree” was a popular poster on the site who liked to share ordinary challenges in her life, challenges that became stranger and stranger as she began discussing the occult. When she began talking about her parent’s membership in an actual cult and their eventual disappearance, fans started to become concerned. According to Guyism.com, an L.A. Times reporter began to investigate the situation, only to find Bree was actually a 19-year-old actress named Jessica Rose, working for a studio currently known as EQAL.

It seems the trick to successfully pulling off an Internet hoax is to make sure the trick, like having a rich person drop off an overly generous tip or a young girl accidentally texting her father far too much personal info, needs to seem plausible. If it makes a good story, people will want to share it, and, if it isn’t harming anyone, tall tales can entertain. Those who take fiction for fact simply need to remember the old adage: You can’t believe everything you read.

The 6 Most Important Tips on Using the Vine App for Your Small Business

Using the Vine App for Your Small Business

Vine app is one of the latest social media hits, but it is still relatively unknown for the promotion of small businesses. Here is how you can be one of the first to use the Vine app for your small business:

Using the Vine App
  1. Be Creative
    As the Vine app is so new, most users are still posting videos of themselves making their breakfast or catching a Frisbee. People will not be interested in seeing this sort of content over and over again, especially not from a small business owner, so you must be as creative as possible in your content. You can get your business noticed by making an unusual, creative video, but remember that videos can only last 6 seconds maximum, so do not try to fit too much in.
  2. Use Hashtags
    Vine uses the same # hashtag system as Twitter, so make sure that you promote your videos with appropriate hashtags so that they will get viewed as much as possible, more helpful hints.
  3. Use the Vine App to Drive people to your other Social Networks
    Use Vine to encourage people onto the social media platforms where you are able to communicate via more than 6 seconds of video. Use a short teaser clip that gives the name of your YouTube channel, to encourage people to visit your YouTube to be able to see the full clip. Although Vine isn’t currently all that well integrated with other social media platforms, the chances are that as the platform develops, so will the levels of integration, so it pays to be prepared.
  4. Create a How-to Video
    Consider what you are selling before you try to make a “how-to” video. Although these can be simple and effective for some products, a “how-to” video can easily backfire if you have a product that takes more than 6 seconds to explain. Although most “how-to” video creators edit these videos to be a series of stills or very short clips put together, you risk doing your products disservice if you over simplify them too much.
  5. Staff Introductions
    Ask your staff if you can take their pictures or a clip of them saying “hi”, then edit this into one short clip of them all together. This is a very fast and fun way to show off your staff. If it fits in with the business ethos of your company, you can even ask them each to do something bizarre or quirky in their pictures. This will make them instantly recognizable to your customers.
  6. Promote an Event
    If you are planning and promoting an event, you can make a composite video made up of fun photos from the last event that you held. These photos could eventually build up until the final second or two, when you show details of the next event which will be held. Make sure you display these details for long enough, so that anyone who is watching the clip has time to read and remember the details. Remember that unlike YouTube videos, Vine videos will automatically keep repeating until users tap the screen to pause, so this event info won’t be continuously displayed when the clip is over.
Vine App

Using Vine app for your small business promotion can help to get you ahead of the game in a fast-paced marketing environment. Give Vine app a go using the tips above.

How to Buy the Perfect Wrist Watch for You?

How to Buy the Perfect Wrist Watch for You

Buying a wrist watch may seem to be an easy purchase for many of us yet to buy the perfect one for you is something that does not fall in the same category. There are factors that make important considerations while you are on the hunt. Markets are just flooded with all sorts of wrist watches for both men and women.

Buying a wrist watch may seem to be an easy purchase for many of us yet to buy the perfect one for you is something that does not fall in the same category. There are factors that make important considerations while you are on the hunt. Markets are just flooded with all sorts of wrist watches for both men and women. There are countless makes and models of wrist watches to suit the taste and style of different people. If you are a woman you will find a complete range of women watches.

Perfect Wrist Watch

If you are looking for men watches you will get an immense number of watches specifically designed for men’s taste and style. Even for kids and young ones there are watches that are crafted keeping in mind this target market. Then there is not a single aspect of purchase; there is functionality, aesthetics, design, color and also mechanism on which a watch operates. However, there are certain points and if you are clear about those the process will surely be a seamless task.

Use of the Wrist Watch: In a glance this question may feel ridiculous yet it sure does make an important consideration. You will need a different style watch if you are doing to buy it for casual use. The criteria will be functionality and durability as the first priority. If you want a watch which you can use while doing sports then functional aspect will be the ultimate criteria. On the other hand if you are one of those people who spend most of their time in the office perhaps a dress watch is one you should look for, more helpful hints. And still if you are buying a watch and you love to express yourself by wearing the style then a luxury designer watch will make the best choice for you.

Material of the Wrist Watch: Wearing such a watch is something like our clothes. You cannot wear one that your corporeal self does not feel good in. Wrist watches are available in different kind of material ranging from material like stainless steel to leather, plastic to rubber, brass to aluminum, canvass to fabric and silver to gold. It is entirely up to you to choose one material over the other; just make sure you know its compatibility with your skin. Avoiding buying such watch in the material you are allergic of is the bottom line.

Mechanism of the Wrist Watch: Mode of operation of the such watch makes an important aspect of wrist watch purchase as it is directly linked to its accuracy. Old wrist watches used to make use of kinetic energy which was stored in the spring which either had to wind regularly or was automatic. Modern wristwatches make use of different material to make wrist watch which tells time much accurately as compared to older ones. Today we have quartz wrist watches and the atomic ones which are the most accurate time pieces. Wearer of the Wrist Watches: Last but not the least; who is going to wear it? Wrist watches nowadays are not just timekeeping gadgets these are an expression of your choice and style. What color you like to wear and what style you identify with should be kept in mind while purchasing a wrist watch especially when you want to buy a perfect one!

Living with Diabetes

Living with Diabetes

As a 27 year old married graduate student, having diabetes really complicates things for me. I found out I have both Diabetes mellitus and Diabetes insipidus. The first one is sugar diabetes while the other one is water diabetes. When I first found out I had either, I was scared and angry with myself. Why did I let this happen? How will this make life difficult? I only have myself to blame. Then, looking back over the years prior to that day, I realized how diabetes insipidus has played a part in all the complications I had gone through so far.

Up until the age of fourteen, the Diabetes insipidus caused me to suffer from wetting the bed. I went to doctor after doctor and was constantly told I had urinary infections and got medication for it. But it kept returning. I couldn’t go to a friends house for slumber parties because I was too embarrassed for wetting the bed. I was finally given a medication to take each night that picked up what my body couldn’t make. It was a certain hormone that everyone’s body creates that controls the bladder while sleeping, but my body didn’t have it. This medicine made up for that. I was also constantly thirsty. I had to have something to drink almost at all times. I also had to go to the bathroom a lot. This still continues to this day. To find out new information about diabetes, check these guys out.

Diabetes

Up until the last couple of years, I didn’t take the diabetes mellitus seriously. As a result of neglecting myself, my body has suffered a great deal. I have developed polycystic ovarian syndrome which has caused it to be more difficult to get pregnant. I have also struggled with hormonal problems. I don’t have energy like I should and I’m always sleepy because my sugar is high. I am at a risk of having a heart attack or a stroke, even at such a young age. Every time I go to my doctor.he tells me that if I lost weight and get my sugar diabetes under control, the cysts on my ovaries would decrease. But it isn’t that easy.

So now, I am taking it seriously. I can’t risk having a heart attack or a stroke. I want to be a mom. I have to be sure to have insulin with me at all times. I have to carry a sugar meter around with me as well. Some days it is easier than others. Some days, I have more energy than others. I used to get angry at the unfairness of it all. Other people can have desserts and goodies. But I can’t. I have to eat non-sugar foods. But now I know it doesn’t do me any good to get angry. I have to deal with it. Being angry isn’t going to change things.

Since learning I have both types of diabetes, I don’t struggle as much with the history of bed wetting up until such a late age. I understand. I am finally taking control and have vowed to lose weight. I have made up my mind to take my body back and live as happily as possible. With my loved ones, I have the strength and support to make it.

Filtering Text Messages with Whatsapp plus: How to Keep Private All Your Required Messages

How to Keep Private All Your Required Messages

Whatsapp plus is the most popular messaging application in the world. It’s been in use for more than 10 years and has over 1 billion active users. Whatsapp plus offers great features which make it stand out from other messengers like Facebook messenger, Skype or Telegram. One of these features is a filter option that helps you keep your required messages while deleting all others from your device with just one click!

Whatsapp plus messenger?

Whatsapp plus messenger

In this article, we’ll talk about whatsapp plus messenger and other features of the app. What is Whatsapp Plus? It is a powerful messaging application which offers all types of features available in WhatsApp as well as many more to make your chatting experience better than ever! You can send secure messages with end-to-end encryption.

The best features of Whatsapp plus

You can transfer data with Whatsapp servers without any third party access.
Plus you will never have to worry about the app being closed or out of storage space, because it supports unlimited files including images and videos!
It is also an excellent replacement for your old WhatsApp messenger.

The best alternatives to Whatsapp

Whatsapp plus is the most famous e app, which is used to send and receive messages. But if you want an alternative of whatsapp then there are some best alternatives of this Whatsapp plus apk for Android phones.

How can I install Whatsapp plus on my Personal Computer or Laptop?

Before installing Whatsapp plus on your personal computer, you have to download whatsApp APK. Download the app from Google Play store or similar application stores like Aptoide Market and Appstore for Android. After downloading this, open it and click on “Install” button which will start installation process of WhatsApp Plus messenger.

What is the Whatsapp plus used for?

What is the Whatsapp plus used for

Whatsapp plus is a new method to filter your messages. You can choose and delete all the message you want by clicking on the option of ‘delete’. This will help you save whatsapp plus apk latest messages in case if someone is trying to hack into your account.

Keeps private all required messages

Deletes unwanted text without any third

How to open Whatsapp plus without a smartphone

Its is easy to open whatsapp plus without a smartphone.

-Install Whatsapp Plus on your PC or Mac and sign in using the mobile number which you want to use for WhatsApp Plus account

-This app will first ask permission of accessing your contacts, so give permissions if needed

-Now it will again prompt for contact access, click deny this time

Whatsapp plus is the ultimate solution for all your messaging needs. It has a host of features that will make you want to stay on this app forever! Whether it’s sharing photos or videos, sending voice messages or saving files from other apps, whatsapp plus does it all without breaking a sweat. With so many amazing options available on this one app, there really isn’t anything else like it out there. What are some of your favorite things about whatsapp? Let us know in the comments below and share with our community what makes this messenger stand out above the rest!

How to Use a Router Safely

How to Use a Router Safely

A wood router is a very versatile and important power tool for those special design cuts, such as raised panels, bevels, and dovetails. It can also serve as a handy tool in sign-making and other scribing projects. How to use a router safely and efficiently depends on respecting its power and understanding how it works. Here are some tips for using a router that will save wasted effort and material and prevent injury.

Tip #1:

One of the more important tips for using a router is to always use safety glasses or goggles when using any power tool in wood work. Ear protection is also strongly recommended in router tips because they run at a very high decibel level.

Tip #2:

torque of a router

The piece being routed must always be secured. The torque of a router will throw the wood if it’s not clamped down, and the router can also be thrown out of the hands. This is very important for those learning how to use a router.

Tip #3:

Router tips must include never touching a spinning bit, and waiting until the bit cools before changing it. Be sure to keep the cord away from the bit as well.

Tip #4:

It is always recommended to make gradual cuts. This prevents drag on the motor and dulling of the bit. Start with a smaller bit and make several passes, gradually increasing the size of the bit. This is how to use a router wisely.

Tip #5:

Do not turn on the router when the bit is in contact with the wood. This will also throw the piece being worked on or the router itself. This is how to use a router in the safest possible way.

Tip #6:

Tips for using a router safely include moving the router in the opposite direction of the spin of the bit. The router will race out of control if moved in the wrong direction, learn more.

Tip #7:

Always make a test cut on a scrap piece of wood before starting on the work piece. This will avoid wasting material and will help to ensure the right bit is being used and the desired depth is being achieved.

Tip #8:

How to use a router safely also includes never holding a work piece with one hand and the router with the other hand. Clamp smaller pieces to a workbench or router table. Both hands must stay on the router at all times.

Tip #9:

working near the edge

When working near the edge of a piece, use another wood piece of equal width to support the router. Clamp the support piece directly against the edge(s) of the work piece. This is one of the more practical router tips.

Tip #10:

Router tips include using a guide piece when necessary, especially for intricate cuts. Clamp a separate piece of wood to the top of the work piece and position it to guide the router.

Stained Bed Sheets: What to Do with Them

Stained Bed Sheets

Do you have a set of stained bed sheets that you don’t know what to do with? Chances are you do. You have probably scrubbed to remove the stains without any luck. You might have even put your stained sheet set up for sale in a rummage sale, hoping nobody would notice the stain, but they did.

Still, your stained bed sheet set sits in your closet because you really don’t want to throw out a perfectly good set of sheets due to a stain, right? Well, you don’t have to throw the sheets set out. You can put the bed sheet set to good use in other ways. Here’s how:

What to Do with Them

Mix and match. Who says that you can’t mix and match your sheet colors? Add some personality to your bedroom and mix the unstained top sheet with an unstained fitted sheet, and you’ll have a whole new bed sheet set to enjoy.

Make a baby blanket. Have you ever bought a thin baby blanket for summertime use? If so, you probably paid a whopping $10 or more. Why not use the unstained part of your bed sheet to make a summertime baby blanket.

All you have to do is trim the edges, or you can even double it up for a more solid weight. Either way, you’ll have a nice summertime baby blanket for about half the cost of a regular, store-bought blanket, and you’ll put your bed sheet to good use.

Sew some bloomers. Do you have a baby (or know someone who has a baby)? If so, use the unstained part of your bed sheet to sew up a pair of bloomers to go with that short baby top that failed to come with a pair of bloomers. This will help dress up the top.

Create a pajama set. If you have a small person in your house, you can use the unstained part of your bed sheet to sew up a set of pajama bottoms or a pajama top for summertime use. You might even be able to sew up both for a really small person.

So, if you have a stained set of bed sheets stuffed up in your closet, don’t let them sit there and ruin. Use the bed sheet set. You don’t have to try and hide the stain, and you don’t want to lose good money by trying to pass off your stained bed sheet set to someone else. Just cut out the stain and use the good material for other useful things.

Independently-Owned Coffee Shops in Clear Lake, Texas

Independently-Owned Coffee Shops in Clear Lake, Texas

NASA Not the Only Reason to Visit this Houston Suburb

If you’ve heard of Clear Lake, Texas, it’s most likely because it is home to NASA’s Johnson Space Center. While Clear Lake, a suburb of Houston, is teeming with aeronautical engineers and aspiring astronauts, it’s also brimming with several good independently-owned coffee houses. So, if you are a Clear Lake coffee drinker in search of a something new or if you’re visiting from out of town, check out these Clear Lake coffee shops if you haven’t already:

Coffee Oasis:

If decent coffee and tasty sandwiches are what you crave, pay a visit to Coffee Oasis on NASA Parkway. Coffee Oasis usually brews about 3-4 different types of coffee each day, so whether you prefer fair trade, decaf, or classic Columbian, you can usually find what you are looking for. If you are in the market for some evening entertainment, stop in on Tuesday nights and check out the Open Mic Night performers. Or pick up the microphone yourself! While you are there, Rusty, the owner, will most likely greet you and engage you in a little friendly banter. There is a kid’s corner with toys and books, as well as a large meeting room in back that can be reserved for work meetings or other gatherings. People of all ages and walks of life frequent this local favorite, making it a comfortable place for anyone to visit.

Pachamama’s:

Pachamama’s is a Clear Lake coffee shop that marches to the beat of a different drummer. Located across from the Johnson Space Center on Upper Bay Road, this cozy, one-of-a-kind coffee shop is definitely not akin to your average corporate coffee chain. In fact, it aspires to be the exact opposite. All coffee here is organic and fair trade. Cow’s milk, sugar, artificial sweetener, and decaf coffee are nowhere to be found. If you take cream with your coffee, it’ll have to be in the form of hemp or soy milk. You want sugar with that? It’ll have to be agave nectar, honey, or sucanat. That’s the way Pachamama’s rolls! If you are hungry, ask about their selection of organic bagels and salads. The menu is limited, but you’re guaranteed a meal that is a treat to your body and soul. Pachamama’s is definitely the most eclectic and relaxed Clear Lake coffee shop!

Paradise Coffee:

Paradise Coffee

This Clear Lake coffee shop is a relatively new addition to Clear Lake and fairly mainstream in its approach to coffee and espresso drinks. Located on Clear Lake City Boulevard, this coffee local has decidedly tropical and refreshing look and feel, which was inspired by the owners’ travels to Hawaii. The Paradise Coffee menu includes hot breakfast items, sandwiches, salads, and kids’ meals. Friendly, knowledgeable baristas and a clean, fresh environment make this Clear Lake coffee shop worth a visit.

So, if you are in the mood for something other than the predictable coffee shop experience, try a visit to one of the unique coffee shops in Clear Lake, Texas. Take a book, grab a friend, or plug-in your laptop. Any of these three Clear Lake coffee shops are sure to provide you with a hot cup of joe and a pleasant ambiance.

Stem Cell Therapy in Orthopedics

Many patients seen by orthopedic surgeons would benefit from tissue regeneration. In the U.S., over 33 million injuries occur every year, and about half involve damage to ligaments, tendons and cartilage. Bone has a high capacity for self-repair, but soft tissues do not. Instead, you get scar tissue, arthritis and limited mobility. It is felt that stem cells would provide better tissue regeneration without scarring and related problems. The stems cells used are called mesenchymal, and are harvested from adults, not fetuses,You can get more information on pain by browsing our website.

Bones

Bones

Bone marrow stem cells can be used to regenerate broken or missing bones. Animals with birth defects affecting their large bones have been successfully treated this way. Other sources of mesenchymal stems cells (MSC) include fat tissue and skeletal muscle. Scientists have found that the stromal vascular fraction of adipose tissue has exciting potential for regeneration procedures, due in part for its ability to build blood vessels as the bone grows. Human bone morphogenetic protein-2 shows great promise for promoting bone ingrowth and storage of osteoinductive molecules. To help this protein generate higher amounts of osteoinductive molecules, scientists have been able to apply gene-splicing techniques that cause overproduction of the desired molecules.

Cartilage

Cartilage is a lot trickier than bone when it comes to regeneration. It has poor intrinsic healing capacity, making it a prime target for stem cell-based regeneration. One technique is to stimulate MSC from the marrow to differentiate into cartilage and heal the defect. The results are only so-so, since the repair doesn’t have a lot of strength. Surgeons now prefer replacement over stimulation, using native tissue from nearby healthy locations. However, replacement presents its own set of problems, including:

  • Long-term complications
  • Damage to the donor site
  • Scarcity of replacement tissues
  • Tissue mismatches


Other Tissues
Other tissues, such as meniscus, ligament and tendon are also under study. The basic idea is to add MSC-loaded scaffolds to the damaged tissues. Some success has been seen with this approach, especially with respect to meniscal repair. Scientists don’t fully understand all of the functions provided by MSC, such as their immunomodulatory and tropic capacities. Researchers are excited by the MSC secretions that contain high amounts of cytokines and growth factors. These cells help suppress the body’s natural immune defense, thereby decreasing incidence of tissue inflammation and rejection. At present there are almost 40 clinical trials occurring worldwide to study MSCs as a means for tissue regeneration, with many more in the works.

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